Analytical Chemistry & Drug Development

Advancements in Liquid Chromatography and Mass Spectrometry

Liquid chromatography (LC) coupled to mass spectrometry (MS) or tandem mass spectrometry (MS/MS) is a well-established and widely used technique in clinical and forensic toxicology as well as doping control especially for quantitative analysis. In recent years, methods for LC–MS(/MS)-based systematic toxicological analysis using triple quadrupole or ion trap instruments have been considerably improved and a new screening approach based on high-resolution MS analysis using bench top time-of-flight MS instruments has been developed.